Polyendocrinopathy

Clinical information

Autoimmune polyendocrinopathies are characterised by the immunological destruction of endocrine tissues. They are characterised by the association of at least two endocrine diseases and the presence of one or more autoantibodies against endocrine organs as well as parietal cells of the stomach and striated muscle.

Diagnostics

The indirect immunofluorescence test (IIFT) on frozen sections of the organs adrenal cortex, ovary, placenta and testis is the main detection method for autoantibodies against steroid hormone-producing cells. The additional use of tissue sections of thyroid and parathyroid gland, pancreas and striated muscle enables parallel detection of numerous associated autoantibodies.

Selected Products

MethodParameterSubstrateSpecies 
IIFTthyroid gland
(MAb + TAb)		thyroid glandmonkeyDetails
IIFTthyroid gland (MAb + TAb)
mitochondria (AMA)		thyroid gland
kidney
(2 BIOCHIPs per field)		monkey
rat
Details		Details
IIFTPolyendocrinopathy Mosaic
thyroid gland (MAb + TAb)
pancreas islets
adrenal cortex
ovarian antigens
Leydig cells
parietal cells (PCA)		6 BIOCHIPs per field:
thyroid gland
pancreas
adrenal gland
ovary
testis
stomach		monkey
monkey
monkey
monkey
monkey
monkey		Details
IIFTEUROPLUS
thyroid gland (MAb + TAb)
thyroglobulin (TG)		2 BIOCHIPs per field:
thyroid gland
TG BIOCHIPs		monkey
human		Details
ELISAthyroid peroxidase
(TPO)		antigen-coated
microplate wells		Details
RIAthyroid peroxidase (TPO)
coated tubes (CT)		antigen-coated
tubes		Details
RIAthyroid peroxidase (TPO)
magnetic separation		labelled antigenDetails
ELISAthyroglobulin
(TG)		antigen-coated
microplate wells		Details
RIAthyroglobulin (TG)
coated tubes (CT); IRMA		antibody-coated
tubes		Details
RIAthyroglobulin (TG)
coated tubes (CT)		antigen-coated
tubes		Details
RIAthyroglobulin (TG)
magnetic separation		labelled antigenDetails
ELISATSH receptor
(thyrotropin receptor)		antigen-coated
microplate wells		Details
ELISATSH receptor
(thyrotropin receptor)
Fast ELISA		antigen-coated
microplate wells		Details
RIATSH receptor
coated tubes (CT)		antigen-coated
tubes		Details
ELISAfree triiodothyronine (FT3)antibody-coated
microplate wells		Details
RIAfree triiodothyronine (FT3)
coated tubes (CT)		antibody-coated
tubes		Details
ELISAreverse triiodothyronine (RT3)antibody-coated
microplate wells		Details
ELISAfree thyroxine (FT4)antibody-coated
microplate wells		Details
RIAfree thyroxine (FT4)
coated tubes (CT)		antibody-coated
tubes		Details
RIATurbo thyrotropin (TSH)
coated tubes (CT); IRMA		antibody-coated
tubes		Details
RIAcalcitonin
coated tubes (CT); IRMA		antibody-coated
tubes		Details
IIFTparathyroid glandparathyroid
gland		monkeyDetails
IIFTEndocrinology Screen (AM) EUROPattern
adrenal cortex		1 BIOCHIP per field:
adrenal gland		monkeyDetails
IIFTadrenal cortexadrenal glandmonkeyDetails
IIFTovarian antigensovarymonkeyDetails
IIFTspermatozoasmearsmearDetails