Anti-CCD absorbent is an additional reagent designed for the incubation with blot-based allergy profiles. The absorbent eliminates anti-CCD IgE antibodies from patient serum, which increases the specificity of test results if these antibodies are present in the sample.

Anti-CCD IgE antibodies are directed against sugar structures of proteins and can be detected in around 25 % of allergy patients as well as in non-allergic individuals. They generally have no clinical relevance.

In extract-based in vitro allergy diagnostics, these antibodies complicate the interpretation of positive results because the following cases cannot be differentiated:

• positive reaction caused by IgE antibodies against peptide epitopes
• positive reaction caused by anti-CCD IgE antibodies
• positive reaction caused by a combination of the two antibody types

Differentiation between the described reactions is possible if the absorbent is used and the anti-CCD IgE antibodies are eliminated.

The anti-CCD absorbent is useful if the patient sample demonstrably contains IgE antibodies against CCD structures. This is indicated by a positive CCD band on the incubated allergy profile. In this case, the serum should be retested using the anti-CCD absorbent.